mark of Cain noun3 •A mark of divine protection imposed on Cain, a biblical figure, for murdering his brother Abel.The Bible vaguely describes the mark of Cain; it does not specify its exact nature. •A stigma of shame.When the engineer's design failed, he received a mark of Cain causing others to choose not to work with him. •(offensive, no longer used) The darker skin found on people of non-European descent, believed to result from being a supposed descendant of Cain.That the descendants of Cain were black, inheriting the mark of Cain. — 1849 formsMarks of Cain · marks of Cain