manifest destiny noun 3verb 1forms 3 noun3 •The political doctrine or belief held by the United States of America, particularly during its expansion, that the nation was obviously destined to expand toward the west. •The belief that God supports the expansion of the United States of America throughout the entire North American continent except Mexico. •The political doctrine or belief held by many citizens of the United States of America that their system is best, and the idea that all humans would like to become Americans. verb1 •(informal) To exercise and realize manifest destiny; to enable the cultural and political expansion of the United States of America.The Homestead Acts allowed millions of settlers to populate unclaimed land and manifest destiny out on the frontier. formsmanifested destiny · manifesting destiny · manifests destiny