malignancy

noun3

1. •
   The state of being malignant or diseased.
2. •
   A malignant cancer; specifically, any neoplasm that is invasive or otherwise not benign.
3. •
   That which is malign; evil, depravity, malevolence.

   • [T]he malignancie of my fate, might perhaps distemper yours; […] — 1601