louse up /ˈlaʊs ˈʌp/ verb2 •(informal) To mess up; to confuse; to put into a state of disorder.To be loused up by Humbolt was really a kind of privilege. It was like being the subject of a two-nosed portrait by Picasso, or an eviscerated chicken by Soutine. — 1976 •(US, informal) To mistreat (someone). formsloused up · lousing up · louses up