lose the plot verb2 •(UK, informal) To cease to behave in a consistent or rational manner.I lost the plot for a while then. And I lost the subplot, the script, the soundtrack, the intermission, my popcorn, the credits and the exit sign. — 1995 •(UK, informal) To lose sight of an important objective or principle; to act contrarily to one's own interests through concentrating on relatively unimportant matters. formslost the plot · losing the plot · loses the plot