long-term potentiation noun1 •A long-lasting (hours in vitro, weeks to months in vivo) increase, typically in amplitude, of the response of a postsynaptic neuron to a particular pattern of stimuli from a presynaptic neuron.Long-term potentiation, like sea-slug learning, absolutely depends on a change in the properties of synapses, in this case the synapses between the inputting cells and the pyramidal cells. — 1999