locked-in syndrome noun1 •A rare, severe physical disorder in which a person cannot speak and is paralyzed—with the possible exception of some voluntary eye movement—while their mental faculties remain fully intact.A a^([sic]) 58-year-old victim of locked-in syndrome has told the high court that a decision not to allow him to be helped to die would condemn him "to a 'life' of increasing misery". — 2012