large and in charge adjective2 •Dominating or controlling a situation with confidence and aplomb.Sure, as the captain of your ship, you are the one to blame when things go wrong or fall apart, but you are also large and in charge when they go well. — 2011 •Of a person, domineering and of heavier weight than average, and who uses their physical presence as a buttress to authority, sometimes used as pejorative towards women.Garfield Large & in Charge. — 2011