knock oneself out verb1 •(informal) To go ahead; to do as one pleases; to enjoy oneself; to endeavor very hard at a task."These cookies are my favorite! Can I have some?" "Sure, knock yourself out." (i.e., have as many as you want)(sarcastically, indicating lack of interest) "I'm going to the store." / "Knock yourself out." formsknocked oneself out · knocking oneself out · knocks oneself out