interstitial space noun4 •An in-between space. •(architecture) The gaps between buildings/floors in architecture, used for systems and movement; the neglected or overlooked spaces between built structures, like alleys, courtyards, or empty lots. •(anatomy) The fluid-filled area between cells in tissues (interstitium). •(sociology) The informal, transitional zones where people from different groups or fields (e.g., hobbyists, professionals) interact. formsinterstitial spaces