instant loss 2koma noun2 •(slang) A two-panel comic depicting a character who displays smugness or overconfidence in the first panel, only to be defeated or humiliated in the second.The cereal spitting guy was the original instant loss 2koma — 2022 •(slang) A pornographic variant of this type of comic, in which the losing character is sexually dominated in the second panel. formsinstant loss 2komas