hysterosalpingo-oophorectomy UK /ˌhɪstərəsalˌpɪŋɡəˌəʊ.əfəˈrɛktəmi/US /ˌhɪstərəsalˌpɪŋɡəˌoʊ.əfəˈrɛktəmi/ noun1 •A surgical procedure that involves the removal of the uterus, fallopian tubes, and ovaries, typically performed to treat severe gynecological disease such as cancer, advanced endometriosis, or other conditions affecting the female reproductive system. formshysterosalpingo-oophorectomies