hot zone noun3 •An area to which access is restricted because it is contaminated with radiation or a chemical or biological biohazard.Medical monitoring is an essential aspect to conducting operations in the hot zone. — 2004 •An area where fighting or hostilities are likely to erupt.Any spot I could point to on a map was about to turn into a hot zone. There was too much trougle brewing for it not to bubble over, and by the summer of 2012, I had a major decision to make. — 2014 •An apparatus for growing crystals at very hot temperatures.The “hot zone” is the key part in controlling the growth process, the melt and gas flow, and the concentration of the intrinsic point defects and their aggregates. — 2014 formshot zones