hit a home run verb3 •To hit a ball during an at-bat that results in all runners on base and the hitter scoring runs; the best result of an at-bat.He was the first pinch hitter to hit a home run on the first pitch of his career. — 2016 •(informal, figurative) To achieve the best possible result. •(slang, figurative) To engage in sexual intercourse. formshitting a home run · hits a home run