handcuff /ˈhændˌkʌf/verb 2noun 1forms 3 verb2 •To apply handcuffs to someone. •(figurative) to restrain or restrict.Dang, I’m handcuffed by these regulations. I’d like to help but it’d be illegal. noun1 •One ring of a locking fetter for the hand or one pair. formshandcuffed · handcuffing · handcuffs