guinea pig /ˈɡɪni pɪɡ/ noun5 •Any tailless rodent of the genus Cavia, which have short ears and superficially resemble large hamsters. •A domestic guinea pig, Cavia porcellus, often kept as a pet. •(figurative) A living experimental subject.He became a human guinea pig and was paid by the company. •(slang, old-fashioned) A professional company director, without time or real qualifications for the duties. •(no longer used) A midshipman in the East India service; (by extension) a low-skilled or non-proficient seaman.A good seaman he is... none of your guinea-pigs. — 1748 formsguinea pigs · guinea-pigs