Guillain-Barré syndrome UK /ˈɡiː.ãˈbær.eɪ ˌsɪn.drəʊm/US /ɡiːˈæn bəˈɹeɪ ˈsɪndɹoʊm/ noun1 •Rapid-onset muscle weakness, often severe and sometimes fatal, resulting from impaired peripheral nervous system function, associated with various viral and other infections.