give it up verb3 •(slang) To hand over or relinquish; to explain something or tell a secret. •To welcome onto a stage by cheering or applauding.“Ladies and gentleman, give it up for the next First Lady of New York City!” — 2013 •(euphemistic) To agree to sexual intercourse, especially if reluctantly.My husband thinks it's 'cause they're all raised Catholic and their girls don't give it up easily, except for the prostitutes. — 2009 formsgave it up · given it up · giving it up · gives it up