fly in the buttermilk noun2 •(informal) A black person in a predominantly white group of people.You can do the same in parts of Ward Three and see black folks sprinkled like “flies in the buttermilk.” Two Districts of Columbia, two different realities. — 2008 •Synonym of fly in the ointment (“something that spoils something else”).Discovery of this document was a fly in the buttermilk of Tattenai. — 2013 formsflies in the buttermilk