fluorouracil UK /ˌflʊə.ɹə(ʊ)ˈjʊə.ɹə.sɪl/US /ˌflʊɹ.oʊˈjʊɹ.əˌsɪl/ noun1 •A fluorine-substituted derivative of uracil C₄H₃FN₂O₂ which inhibits DNA synthesis and is used as a chemotherapy drug in the treatment of cancer. formsfluorouracils