flesh and blood noun 4adjective 2 noun4 •A human body; a person generally. •One's family, or member of one's family.How dare you say such a thing to your own flesh and blood? •Human nature. •(slang, no longer used) A mixture of brandy and port in equal quantities. adjective2 •Consisting of flesh, blood, and other substances associated with animals or humans. •(figurative) Real; substantial.