estrange /ɪˈstɹeɪnd͡ʒ/ verb2 •To cause to feel less close or friendly; alienate. To cease contact with (particularly of a family member or spouse, especially in form estranged).And thou thyself, Jaacob Yitzchak, dost thou mind how thou meantest to follow me and estrangedst thyself from me the more? — 1945 •To remove from an accustomed place or set of associations. formsestranged · estranging · estranges · estrangeth · estrangest