distempered /dɪsˈtɛmpəd/ adjective1 •(no longer used) Affected with or suffering from distemper.I, sick withal, the help of bath desired, And thither hied, a sad distemper’d guest, But found no cure: the bath for my help lies Where Cupid got new fire—my mistress’ eyes. — 1609 formsmore distempered · most distempered