diphenoxylate /ˌdaɪˌfɛnˈɑk.səˌleɪt/ noun1 •An antidiarrheal agent (trademark Lomotil) chemically related to pethidine and administered in the form of its hydrochloride C₃₀H₃₂N₂O₂·HCl in combination with the sulfate of atropine.