dickkopf UK /ˈdɪkˌkɒpf/US /ˈdɪkˌkɑ(p)f/ noun1 •Any of a family of glycoproteins that are involved in the development of the embryo.Here we describe dickkopf-1 (dkk-1), which encodes Dkk-1, a secreted inducer of Spemann's organizer in Xenopus and a member of a new protein family. — 1998 formsdickkopfs