crime against humanity noun2 •A very destructive and immoral act; later specifically, something causing widespread human misery or loss of life; an atrocity.The Holocaust was a terrible crime against humanity; it took the lives of 6 million Jews, 2 million Poles, and hundreds of thousands of Gypsies, homosexuals, Russians, and the elderly and disabled. •(informal, humorous) Something objectionable.“Pineapple on pizza is a crime against humanity,” Leo's voice is flat. Which is weird, because he usually adds “Fight me” at the end of that declaration. — 2021 formscrimes against humanity