cootie /ˈkuːti/ noun4 •(informal, slang) A louse (Pediculus humanus). •[usually plural] (US, informal) Any germ or contaminant, real or imagined, especially from the opposite gender (for pre-pubescent children).I’m not drinking from his glass until I wash the cooties off it. •(rare) A nest-building female American coot (counterpart to cooter). •(slang, rare) A sideswiper, a type of telegraph key. formscooties