colocynth UK /ˈkɒ.lə.sɪnθ/US /ˈkɑ.lə.sɪnθ/ noun2 •A viny plant, of species Citrullus colocynthis, native to the Mediterranean Basin and Asia. It produces a lemon-sized, yellowish, green-mottled, spongy, and extremely bitter fruit. •The powdered pulp of this fruit, a powerful hepatic stimulant and hydragogue cathartic used as a strong laxative. formscolocynths