chain reaction noun3 •A chemical reaction where the products of the reaction influence the reactants of a following reaction, leading to positive feedback. •A nuclear reaction in which particles produced by the fission of one atom trigger fissions of other atoms.The Manhattan Project produced the first recorded controlled chain reaction. •(figurative) A series of events, each one causing or influencing the next.You need the evening action / A place to dine, a glass of wine, a little late romance / It's a chain reaction / You'll see the people of the world coming out to dance — 1980 formschain reactions