cell-adhesion molecule noun1 •Any of a class of cell-surface proteins, typically glycoproteins, which enable and/or stabilize physical connections between cells or between a cell and an acellular material, such as an extracellular matrixIn order for cells in tissues to function in an integrated manner, specialized junctions consisting of clustered cell-adhesion molecules are essential. — 2000 formscell adhesion molecules · cell-adhesion molecules