amidophosphoribosyltransferase /əˌmiːdoʊˌfɒsfəˌraɪbəʊzɪlˌtrænsfəˈreɪs/ noun1 •An enzyme that catalyzes the first committed step in purine synthesis, converting PRPP and glutamine into a precursor used to make purine nucleotides such as adenine and guanine.