acetazolamide UK /əˌsiː.təˈzɒl.əm.ʌɪd/US /ˌæs.ət.əˈzoʊ.ləˌmaɪd/ noun1 •A drug that inhibits the enzyme carbonic anhydrase, used in the treatment of glaucoma and epilepsy and as a diuretic (now especially in the prevention of acute mountain sickness). formsacetazolamides